HPTA Shutdown

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  • GoHard24/7

    HPTA Shutdown

    So I started a cycle of Tren Acetate @50mg's eod. I noticed after 2 weeks my body wasn't acting right. Without being to graphic my semen looks like water at this point. I'm getting some nlovadex tomorrow with this be enough to restart my body or should I take something else as well. How long does it take for your body to start producing again and will I notice any long term effects from this? Sorry if I sound like a newbie I am I've only take test boosters before and then I took this and wow I was surprised at the side effects. Thanks for the help.
  • Darkness
    Moderator
    • Apr 2011
    • 5657

    #2
    Hi.

    Are you taking test with that tren A? if you are not that's a bad idea. Should have a test base. You can research why if you wish. No question you would have felt highly shittish if no test with the tren.

    In addition, I wouldnt get the nolva too close to the tren. That can be a recipe for gyno as Nolva will upregulate the progesterone receptor. Get Clomid to PCT with that. HCG might be a good idea but I dont know if you will need it given you implied you only ran the tren for 2 weeks.

    So tell us more...what all were you running in this cycle?

    Comment

    • GoHard24/7

      #3
      I was only running the Tren A yeah I didn't have a test base kinda stupid I know now. I didn't realize this shit would shut me down so fast, I picked up Viridex XT which is an otc test booster. I'm hoping this will get me fixed, I was told to take the nolva instead of clomid just because you can get the same results with 20mg's a day instead of 150mg's which seems like your wasting money to me. Will taking this test booster fix my issue to get back on the track of making my own test again?

      Comment

      • Darkness
        Moderator
        • Apr 2011
        • 5657

        #4
        For how long did you run the Tren A? I am not sure who is coaching you, but no the test booster is not suited to this application at all.

        The reason you want Clomid instead of Nolva for PCT close to a 19nor compound like Tren is that, like I stated above...never mind, the reason is you might grow a lactating titty, OK?

        So if you ran the tren for a number of weeks, and were in your situation, I'd do this for PCT:

        1-3 HCG 500iu 2x/week
        1-6 Clomid 50mg ED

        Comment

        • liftsiron
          Administrator
          • Nov 2003
          • 18443

          #5
          Nolvadex (Tamoxifen Citrate): Increases Expression of Progesterone Receptor

          Aromatase Inhibitors: Cellular and Molecular Effects

          Marked cellular and molecular changes may occur in breast cancers following treatment of postmenopausal breast cancer patients with aromatase inhibitors. Neoadjuvant protocols, in which treatment is given with the primary tumour still within the breast, are particularly illuminating. In Edinburgh, we have shown that 3 months treatment with either anastrozole, exemestane or letrozole produces pathological responses in the majority of oestrogen receptor (ER)-rich tumours (39/59) as manifested by reduced cellularity/increased fibrosis. Changes in histological grading may also take place, most notably a reduction in mitotic figures. This probably reflects an influence on proliferation as most tumours (82%) show a marked decrease in the proliferation marker, Ki67. These effects are generally more dramatic than seen with tamoxifen given in the same setting. Differences between aromatase inhibitors and tamoxifen are also apparent in changes in steroid hormone expression. Thus, immuno-staining for progesterone receptor (PgR) is reduced in almost all cases by aromatase inhibitors, becoming undetectable in many. This contrasts with effects of tamoxifen in which the most common change on PgR is to increase expression. Changes in proliferation occur rapidly following the onset of exposure to aromatase inhibitors. Thus, neoadjuvant studies with letrozole in which tumour was sampled before and after 14 days and 3 months treatment show that decreased expression of Ki67 occur at 14 days and, in many cases, the effect is greater at 14 days than 3 months. These early changes precede evidence of clinical response but do not predict for it. However, this study design has allowed RNA analysis of sequential biopsies taken during the neoadjuvant therapy. Based on clustering techniques, it has been possible to subdivide tumours into groups showing distinct patterns of molecular changes. These changes in tumour gene expression may allow definition of tumour cohorts with differing sensitivity to aromatase inhibitors and permit early recognition of response and resistance.

          Ref: Breast Unit, Western General Hospital, Edinburgh, Scotland, UK (w.r.miller@ed.ac.uk)
          ADMIN/OWNER@Peak-Muscle

          Comment

          • liftsiron
            Administrator
            • Nov 2003
            • 18443

            #6
            J Pediatr Endocrinol Metab. 2004 Aug;17(8):1115-9.
            The effect of tamoxifen on sex hormone binding globulin in adolescents with pubertal gynecomastia.
            Derman O, Kanbur NO, Tokur TE.
            Source

            Section of Adolescent Medicine, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey. drderman@hotmail.com
            Abstract

            We investigated the relationship between sex hormone binding globulin (SHBG) and pubertal gynecomastia in 21 adolescents evaluated longitudinally. Thirteen patients were given tamoxifen treatment after grading according to the Nydick classification (group 1). Group 2 consisted of eight patients followed without treatment. Gynecomastia existed bilaterally in 15 patients. There was a statistically significant breast size reduction in both groups. There was a significant decrease in serum SHBG only in group 2. These findings suggest that serum SHBG is increased by tamoxifen treatment in male adolescents. There was a decrease in SHBG levels through the duration of follow up in patients who recovered with or without treatment. However, this decrease was statistically significant in the untreated group, but not in the tamoxifen treated group. In conclusion, we suggest that the pubertal fall in SHBG levels is attenuated by tamoxifen treatment given for pubertal gynecomastia since tamoxifen increases SHBG levels in male adolescents.

            PMID:
            15379424
            [PubMed - indexed for MEDLINE]
            ADMIN/OWNER@Peak-Muscle

            Comment

            • GoHard24/7

              #7
              Darkness I did 6 injections at 1/2 cc each time. Your saying I need HCG but typically thats given to people who have been on a shit ton of cycles not someone who took it for 2 weeks? am I misunderstanding that? I'm just trying to figure out how the fuck to get my nut from water to an actual substance again and this shit is ridiculously confusing. Everyone contradicts everyone. I know I didn't take a test base with this but I have a cycle of Test E and winstrol if I start that cycle will my level increase to the point where my semen isn't like water? I can't find anything online that clearly states what to do.

              Comment

              • GoHard24/7

                #8
                Good news I just finished a session with my girl and it seems like my substance has some substance lol. I'm working on getting the clomid, but I have a cycel of Test E and Winstrol I was wanting to start taking soon. I was looking at taking

                Week 1-10: 600-700mg's of test per week
                Week 1-2: 200 mg's per week
                Week 3-4: 300 mg's per week

                PCT start 2 weeks after the last Test injection Nolvadex @ 40mg's ed

                does this sound like a solid cycle or what could I do different? I guess I'm just a little apprehensive after I saw how my system shutdown after the Tren but everything I've read says Tren does that to you very quickly. Thanks for all the help.

                Comment

                • Darkness
                  Moderator
                  • Apr 2011
                  • 5657

                  #9
                  Originally posted by GoHard24/7
                  Darkness I did 6 injections at 1/2 cc each time. Your saying I need HCG but typically thats given to people who have been on a shit ton of cycles not someone who took it for 2 weeks? am I misunderstanding that? I'm just trying to figure out how the fuck to get my nut from water to an actual substance again and this shit is ridiculously confusing. Everyone contradicts everyone. I know I didn't take a test base with this but I have a cycle of Test E and winstrol if I start that cycle will my level increase to the point where my semen isn't like water? I can't find anything online that clearly states what to do.
                  I suggested HCG because I didnt know how long you ran the tren. If you run a complete cycle of tren HCG is just about a must. If you just ran it two weeks then forget about the HCG. It just took a bit for you to disclose that.

                  I know everyone has an opinion. Can I make a suggestion? Spend some time researching AAS, then all the basic questions you can answer yourself. Also spend some time on boards and get to know some vets. Then you kinda know who knows their shit and who's full of shit. Then you at least are speaking the same language even if you need help. Sometimes there's more than one right answer, but if you stick to one voice and one philosophy, then you got a "program". For example I made a correction to your Nolva plan with the 19nor and liftsiron, a smarter man than I, followed that up with medical evidence of same (I'm not that smart).

                  If you have Clomid coming you are off to a good start, and I predict that you will recover fine from just using that. Dont fuck with 150mg ED my God. 50mg ED will do the trick, just keep it simple. Leave some good time between the end of the Clomid and the next cycle, allowing your body to mormalize. Otherwise you really have not recovered. Tren shutdown is a bitch eh?


                  Serious I want to watch my tone and not come off like I am talking down to you, but serious man you owe it to yourself to learn alot more about these compounds before you start another cycle. The one you laid out looks OK but wait and learn bro. You have just been rescued from a burning building and want to strip off the oxygen mask and rush back inside.

                  Comment

                  • GoHard24/7

                    #10
                    Thanks so much man I appreciate the insight. Good Looking out

                    Comment

                    • Darkness
                      Moderator
                      • Apr 2011
                      • 5657

                      #11
                      Originally posted by GoHard24/7
                      Thanks so much man I appreciate the insight. Good Looking out
                      You are welcome, I enjoy it.

                      Here bro check this out. This is a good read. I wrote this article for a board I modded at because we got lots of PCT questions. It kinda teaches the basic of how and why for PCT and addresses some common broshit.

                      Comment

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