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what better way to pop my cherry over here than fix the thread you guys got going on cancer right???
The following is an IBE exclusive article. Replication of any type is forbidden without authors permission
In response to high demand, here is the truth about cancer that half the Dr's out there don't even grasp at times.
The big misconception about cancer is its something you get. This is not true, we all live with cancer type cells all the time, but our body has its own control over these cells, and kills them off via apoptosis. The things that cause cancer,don't neccissarily make more cancerous cells all the time, some of the time they damage the cells ability to detect, and kill itself if it becomes cancerous. And because of the way DNA is replicated and the flaws in it, this is what happens with age.
The breif summary:
Your body has specific genes, and receptors that regulate programmed cell death through a method called apoptosis. Apoptosis basically results in the destruction of the mitochondrial membrane, destruction of the cellular DNA and eventually your body digest the dead cell with special enzymes, etc. and the cell is gone comepletely without a trace.
This is what your body does when it detects a faulty cell. In the case of cancer these cells have their fault in that they have lost their ability to control their growth cycle. They just keep dividing, over and over. In a healthy individual these cells are detected either by themselves or the body, and it is signaled to under apoptosis. If this doesnt happen and the cells can keep dividing, eventually this leads to a tumor. When they refer to metastisizing in cancer, they are refering to the point at which the cells that were duplicating, at least some of them have broken off and spread throughout the body so that they can now reattach anywhere and start making more tumors.
How do Growth factors and Selegiline fit into the picture. First of all, neither of these cause cells to become cancerous. One could argue that b/c growth factors cause cell growth and progression though the cycle, the more times a cell duplicates the more chances there is for a mistake and a cancer cell made. However you are duplicating cells all the time eveyr day. So really the increased risk there is extremely low. In addition to that, muscle specific growth factors, have even less of a risk, b/c adult muscle cells can not divide. You will never have bicep cancer unforunantly, although it might be nice to have your muscles grow on there own for a while by mistake, it will never happen.
The risk with IGF and selegiline exist primarily on their ability to preserve cell life by upregulating proteins that actually block your bodies apoptotic factors. This is why selegiline and IGF are neuroprotective drugs. They can protect cells from undergoing apoptosis, which in the case of many neurological diseases, is the cause. For unknown reasons these brain cells start undergoing programmed cell death. They are not cancerous. So these drugs are used to treat the condition.
However if a cell in the body was cancerous, it is conceivable that enough singaling via IGF or selegiline could prevent the body from killing it off. Thus it would be allowed to grow in duplicate. This is why I am going to suggest cycling any type of compound that effects tumor surpressors in the body. Because IGF and Selegiline do not permanently effect the ability of the cell to undergo apoptosis, one would assume that discontinued stimulation would then result in the body being able to successfully kill the cells.
So you may ask then, why do people get cancer/tumors if we have such a great mechanism for defense. The flaw is in our gene replication. When DNA replicates often times it leaves off little peices on the ends. So there is a loss of DNA. But the cell has a special enzyme called telomerase that can actually use an imbeded sequence in the enzyme to fix these ends. But this doesnt happen 100% of the time. So as you get older you are actually losing your DNA due to the clipping off or incomplete ends during replication. The biggest downside here, is that two very important genes are close to the ends of the DNA, one codes for telomerase itself, the very thing trying to reduce DNA loss, and the other codes for the p53 gene which is considered the primary tumor surpressor gene. This is the gene most responsible for a cell to be able to program its own death if it becomes cancerous. Loss of this gene= a major loss in cancer defense for this cell and every cell it makes from there on.
So while IGF/and Selegiline due effect tumor supressor action, I beleive cancer if it is going to occur, will happen with or without them present. However long term use if either of these without cycling, could speed up the process considerably. So, what I recommend is the same for any drug. Take as directed. (by me that is lol)
The following is an IBE exclusive article. Replication of any type is forbidden without authors permission
In response to high demand, here is the truth about cancer that half the Dr's out there don't even grasp at times.
The big misconception about cancer is its something you get. This is not true, we all live with cancer type cells all the time, but our body has its own control over these cells, and kills them off via apoptosis. The things that cause cancer,don't neccissarily make more cancerous cells all the time, some of the time they damage the cells ability to detect, and kill itself if it becomes cancerous. And because of the way DNA is replicated and the flaws in it, this is what happens with age.
The breif summary:
Your body has specific genes, and receptors that regulate programmed cell death through a method called apoptosis. Apoptosis basically results in the destruction of the mitochondrial membrane, destruction of the cellular DNA and eventually your body digest the dead cell with special enzymes, etc. and the cell is gone comepletely without a trace.
This is what your body does when it detects a faulty cell. In the case of cancer these cells have their fault in that they have lost their ability to control their growth cycle. They just keep dividing, over and over. In a healthy individual these cells are detected either by themselves or the body, and it is signaled to under apoptosis. If this doesnt happen and the cells can keep dividing, eventually this leads to a tumor. When they refer to metastisizing in cancer, they are refering to the point at which the cells that were duplicating, at least some of them have broken off and spread throughout the body so that they can now reattach anywhere and start making more tumors.
How do Growth factors and Selegiline fit into the picture. First of all, neither of these cause cells to become cancerous. One could argue that b/c growth factors cause cell growth and progression though the cycle, the more times a cell duplicates the more chances there is for a mistake and a cancer cell made. However you are duplicating cells all the time eveyr day. So really the increased risk there is extremely low. In addition to that, muscle specific growth factors, have even less of a risk, b/c adult muscle cells can not divide. You will never have bicep cancer unforunantly, although it might be nice to have your muscles grow on there own for a while by mistake, it will never happen.
The risk with IGF and selegiline exist primarily on their ability to preserve cell life by upregulating proteins that actually block your bodies apoptotic factors. This is why selegiline and IGF are neuroprotective drugs. They can protect cells from undergoing apoptosis, which in the case of many neurological diseases, is the cause. For unknown reasons these brain cells start undergoing programmed cell death. They are not cancerous. So these drugs are used to treat the condition.
However if a cell in the body was cancerous, it is conceivable that enough singaling via IGF or selegiline could prevent the body from killing it off. Thus it would be allowed to grow in duplicate. This is why I am going to suggest cycling any type of compound that effects tumor surpressors in the body. Because IGF and Selegiline do not permanently effect the ability of the cell to undergo apoptosis, one would assume that discontinued stimulation would then result in the body being able to successfully kill the cells.
So you may ask then, why do people get cancer/tumors if we have such a great mechanism for defense. The flaw is in our gene replication. When DNA replicates often times it leaves off little peices on the ends. So there is a loss of DNA. But the cell has a special enzyme called telomerase that can actually use an imbeded sequence in the enzyme to fix these ends. But this doesnt happen 100% of the time. So as you get older you are actually losing your DNA due to the clipping off or incomplete ends during replication. The biggest downside here, is that two very important genes are close to the ends of the DNA, one codes for telomerase itself, the very thing trying to reduce DNA loss, and the other codes for the p53 gene which is considered the primary tumor surpressor gene. This is the gene most responsible for a cell to be able to program its own death if it becomes cancerous. Loss of this gene= a major loss in cancer defense for this cell and every cell it makes from there on.
So while IGF/and Selegiline due effect tumor supressor action, I beleive cancer if it is going to occur, will happen with or without them present. However long term use if either of these without cycling, could speed up the process considerably. So, what I recommend is the same for any drug. Take as directed. (by me that is lol)
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