Peak-Muscle.com  

Welcome to the Peak-Muscle.com forums.

You are currently viewing our boards as a guest which gives you limited access to view most discussions and access our other features. Come join us in on one of the best online fitness communities. We have 16,000 members that are likeminded towards a fitness, bodybuilding lifestyle. Registration is free and only takes but a few minutes. By joining our free community you will have access to communicate privately with other members (PM), respond to polls, upload content and access many other special features. You will be able to create threads to discuss and or create a fitness regimen. Or just bounce ideas off of some very knowledgeable members. So don't miss out. Registration is fast, simple and absolutely free so please, join our community today!

Register FAQ Members List Calendar Arcade Mark Forums Read
Go Back   Peak-Muscle.com > Anabolic Steroid Discussion > Anabolic Steroid Articles and Studies
User Name
Password

Reply
 
Thread Tools Display Modes
Old 02-19-2020, 11:56 AM   #1
liftsiron
Administrator
 
liftsiron's Avatar
 

Join Date: Nov 2003
Location: Cimmeria
Posts: 18,386
liftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant future
TRT Causes Prostate Cancer? Nah. The Opposite

TRT Causes Prostate Cancer? Nah. The Opposite
For years, doctors have told us about the dangers of testosterone replacement therapy. Could they have been completely wrong?
by TC Luoma | 02/16/20

Anybody who's ever lobbied his doctor for testosterone replacement therapy has gotten some version of "the speech," which consists of a warning about TRT possibly causing prostate cancer and the need for frequent, humiliating exams possibly made all the worse because of a freakishly long index finger with knuckles the size of hambones.

That ominous speech is but one repercussion of the work of Charles Brenton Huggins and Clarence Hodges, two researchers from the 1940s who noticed that patients with metastatic prostate cancer lived a bit longer than expected when they were castrated.

This led them – and several generations of doctors that succeeded them – to assume it was testosterone itself that promoted prostate cancer.

I should be a little more specific, though. Huggins and Hodges assumption was based on ONE guy with metastatic cancer who lived longer than he was supposed to because he was castrated. (1) Talk about a paucity of data! Talk about a small sampling size!

Hell, my Uncle Uno died from a heart attack a few hours after eating a bowl of Fruit Loops. You don't see me warning the whole world that Fruit Loops cause heart attacks.

Anyhow, far fewer docs are now furrowing their brows over the alleged connection between TRT and prostate cancer. The studies just don't back it up.

Furthermore, a new study – one that was based on information from a large U.S. commercial insurance research database – found that not only does TRT not correlate with new cases of prostate cancer, it appears it might actually prevent them.
Cancer
What the Database Indicated

The researchers looked at 189,491 men between the ages of 40 and 60 in the IBM MarketScan Commercial Database. (2) Men who had received the greatest number of testosterone injections (more than 12) were 33% less likely to have developed prostate cancer than men who had received the fewest number of injections (1-2).

They also found a similar inverse association between men who had used a testosterone topical gel. Those that used a gel for the longest time (over 330 days) had fewer cases of prostate cancer than those who had used one for a short time (between 1 and 60 days).
What This Means to You

Clearly, this study suggests that testosterone replacement therapy, at least in the short-term, and at clinically accepted levels (no more than 100 to 200 mg. a week), doesn't increase the risk of prostate cancer. In fact, based on the numbers presented, it looks like it actually wards off prostate cancer.

However, as much as I'd like to wholly embrace these findings and sleep better at night, I realize that they may be influenced by possible confounding factors, which is statistics-ese for factors that may mask an actual association, or falsely demonstrate an apparent association where none exists.

Still, these number look pretty damn comforting, especially when matched up with a number of other reports, including another insurance database study that had similar findings. (3) The jury may still be out on whether sane doses of testosterone can cause prostate cancer, but 10 or 11 of the 12 angry men look like they're ready to acquit.
Related:  8 Lies About Testosterone That Need to Die
Related:  The Complete Guide to T Replacement
References

Morgentaler, A., "Testosterone and prostate cancer: an historical perspective on a modern myth," Eur Urol. 2006 Nov;50(5):935-9.
Michael B. Cook, Daniel C. Beachler, Lauren E. Parlett, Philip T. Cochetti, William D. Finkle, Stephan Lanes and Robert N. Hoover. "Testosterone Therapy in Relation to Prostate Cancer in a U.S. Commercial Insurance Claims Database," Cancer Epidemiology, Markers & Prevention, November 25, 2019.
David S. Lopez, Danmeng Huang, Kostas Tsilidis, Mohit, Khera. "Association of the extent of therapy with prostate cancer in those receiving testosterone therapy in a US commercial insurance claims database," Clinicial Endocrinology, 91(6), September, 2019.
__________________
ADMIN/OWNER@Peak-Muscle
liftsiron is online now   Reply With Quote
Old 12-12-2021, 11:27 AM   #2
liftsiron
Administrator
 
liftsiron's Avatar
 

Join Date: Nov 2003
Location: Cimmeria
Posts: 18,386
liftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant future
bump
__________________
ADMIN/OWNER@Peak-Muscle
liftsiron is online now   Reply With Quote
Old 01-11-2022, 05:59 AM   #3
liftsiron
Administrator
 
liftsiron's Avatar
 

Join Date: Nov 2003
Location: Cimmeria
Posts: 18,386
liftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant future
Good read.
__________________
ADMIN/OWNER@Peak-Muscle
liftsiron is online now   Reply With Quote
Old 01-11-2022, 09:43 AM   #4
ozzy69
Assistant Admin
 

Join Date: Jun 2011
Location: Flipping tires in the back yard
Age: 48
Posts: 4,825
ozzy69 has much to be proud ofozzy69 has much to be proud ofozzy69 has much to be proud ofozzy69 has much to be proud ofozzy69 has much to be proud ofozzy69 has much to be proud ofozzy69 has much to be proud ofozzy69 has much to be proud ofozzy69 has much to be proud of
Great read
ozzy69 is offline   Reply With Quote
Old 07-12-2022, 11:10 AM   #5
liftsiron
Administrator
 
liftsiron's Avatar
 

Join Date: Nov 2003
Location: Cimmeria
Posts: 18,386
liftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant futureliftsiron has a brilliant future
up again.
__________________
ADMIN/OWNER@Peak-Muscle
liftsiron is online now   Reply With Quote
Old 07-16-2022, 11:45 AM   #6
Oatmeal77
VET
 

Join Date: Feb 2019
Posts: 47
Oatmeal77 is on a distinguished road
Great post. I get checked regularly. My father and grandfather both had prostate cancer which apparently puts me at a75% chance myself and that's if I didn't use any AAS.
Oatmeal77 is offline   Reply With Quote
Old 07-17-2022, 11:22 PM   #7
Magnesium
Vet
 
Magnesium's Avatar
 

Join Date: Dec 2009
Posts: 367
Magnesium is on a distinguished road
For some reason I think that estrogen is more related to poor outcome with prostate cancer than testosterone. Maybe I read it somewhere, maybe I made it up. Anyway, with testosterone converting to estrogen, higher levels of testosterone mean higher levels of estrogen and presto bango you get the original correlation and reason to cut off balls
Magnesium is offline   Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Forum Jump


All times are GMT -5. The time now is 11:38 AM.


Powered by: vBulletin Version 3.8.11
Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.