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Old 05-31-2020, 01:33 PM   #1
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Treating COVID-19 with hydroxychloroquine, with or without azithromycin, leads to mor

Treating COVID-19 with hydroxychloroquine, with or without azithromycin, leads to more deaths
Michael Walter | April 22, 2020 | Electrophysiology & Arrhythmia

Treating the new coronavirus with hydroxychloroquine is associated with an increase in overall mortality, according to new research involving U.S. veterans. The combination of hydroxychloroquine and azithromycin also led to an increase in mortality.

Hydroxychloroquine, an antimalarial drug, has been repeatedly suggested by President Donald Trump and others as a safe COVID-19 treatment. Recent research, however, has noted that the medication—and similar drugs such as chloroquine—are associated with significant side effects, especially in terms of the patients’ cardiac health. In early April, the American Heart Association, American College of Cardiology and Heart Rhythm Society warned healthcare providers to use caution when considering hydroxychloroquine and azithromycin to treat COVID-19 if the patient has cardiovascular disease.

For this latest study, published on medRxiv and still awaiting a peer review, the researchers assessed data from 368 patients with confirmed cases of COVID-19. All patients were treated at medical centers affiliated with he U.S. Veterans Health Administration through April 11, 2020. Each patient was treated with hydroxychloroquine alone (97 patients), both hydroxychloroquine and azithromycin (113 patients) or no hydroxychloroquine at all (158 patients).

Overall, patients treated with hydroxychloroquine alone experienced a death rate of 27.8%. Patients treated with hydroxychloroquine and azithromycin had a death rate of 22.1%, and patients receiving neither treatment had a death rate of 11.4%. The risk of ventilation was similar for all three groups.

“In this study, we found no evidence that use of hydroxychloroquine, either with or without azithromycin, reduced the risk of mechanical ventilation in patients hospitalized with COVID-19,” wrote Joseph Magagnoli, MS, University of South Carolina, and colleagues. “An association of increased overall mortality was identified in patients treated with hydroxychloroquine alone. These findings highlight the importance of awaiting the results of ongoing prospective, randomized, controlled studies before widespread adoption of these drugs.”

NIH recommends against treatment with hydroxychloroquine, azithromycin

While anecdotal evidence and small studies have suggested the combination of hydroxychloroquine and azithromycin could treat COVID-19 patients, healthcare specialists have noted again and again that there is a lack of clinical data backing up such claims.

In fact, the COVID-19 Treatment Guidelines Panel formed by the National Institutes of Health (NIH) is now specifically recommending against the combination of hydroxychloroquine and azithromycin for patients suffering from this virus. The panel has also said “there are insufficient clinical data to recommend either for or against” the use of hydroxychloroquine or chloroquine alone for COVID-19 patients.

“Although reports have appeared in the medical literature and the lay press claiming successful treatment of patients with COVID-19 with a variety of agents, definitive clinical trial data are needed to identify optimal treatments for this disease,” according to the NIH-backed guidelines. “Recommended clinical management of patients with COVID-19 includes infection prevention and control measures and supportive care, including supplemental oxygen and mechanical ventilatory support when indicated.”
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Old 05-31-2020, 02:07 PM   #2
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That study shows the treatment has double the death rate

Not sure I get it. Why are so many people taking it?
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Old 05-31-2020, 03:07 PM   #3
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The missing link is Zinc has to be supplemented at the same time.
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Old 05-31-2020, 06:10 PM   #4
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The missing link is Zinc has to be supplemented at the same time.
More unproved nonsense.
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Old 05-31-2020, 06:13 PM   #5
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Good info, thanks.
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Old 05-31-2020, 06:22 PM   #6
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Good info, thanks.
Sorry Beef.
Actually zinc maybe the only one of the three meds that has effect. Studies show that elderly people normally have low zinc levels which lower immunity to other covid viruses. So it's makes sense that in theory zinc may help boost immunity in elderly patients. I meant it hasn't been proven that adding zinc to
hydroxychloroquine has any benefit, because hydroxychloroquine still causes a drastic increase to risk of death from caradiac arrhythmia and adding z-pak makes matters even worse.
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Old 05-31-2020, 11:08 PM   #7
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Depends on what you watch, left news says it's worthless and kills you, right news says it has worked for many. Both have their studies. You can't have this conversation about HCQ without it becoming political to some extent IMO. Even IF it doesn't work, I disagree that it causes a higher mortality, and believe there is an agenda there.

The dosage recommended of HCQ is only for 6 days, and it's around the same dose as what lupus patients have been taking for DECADES with no bad sides. I know - I've been taking it for 14 years with no bad sides, and I'm not dead.
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Old 06-01-2020, 02:03 AM   #8
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Depends on what you watch, left news says it's worthless and kills you, right news says it has worked for many. Both have their studies. You can't have this conversation about HCQ without it becoming political to some extent IMO. Even IF it doesn't work, I disagree that it causes a higher mortality, and believe there is an agenda there.

The dosage recommended of HCQ is only for 6 days, and it's around the same dose as what lupus patients have been taking for DECADES with no bad sides. I know - I've been taking it for 14 years with no bad sides, and I'm not dead.
The studies done recently specifically for covid 19 show HCQ doesn’t do shit to treat covid 19 and poses a great risk especially to those with a weaker heart. It’s politics when individuals reject the latest medical studies. The agenda is to cure not kill covid patients. Z pal is also safe for the vast majority of users yet every year a large number of users die from cardiac Q wave elongation. Just because one person can use a drug safely does not mean everyone can.
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Old 06-01-2020, 01:38 PM   #9
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The studies done recently specifically for covid 19 show HCQ doesn’t do shit to treat covid 19 and poses a great risk especially to those with a weaker heart. It’s politics when individuals reject the latest medical studies. The agenda is to cure not kill covid patients. Z pal is also safe for the vast majority of users yet every year a large number of users die from cardiac Q wave elongation. Just because one person can use a drug safely does not mean everyone can.
Wonder why then many front line workers, including doctors were/are using HCQ? The VA study is one, yet there were other studies reported in France, China, Spain that showed positive results. Millions of people have been using HCQ for decades with no ill effects. IIRC, the risks were only people with weak hearts and already in later stages of being very sick. We will just have to agree to disagree on this one Lifts.
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Old 06-01-2020, 01:51 PM   #10
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Originally Posted by Dawgpound_Hank View Post
Wonder why then many front line workers, including doctors were/are using HCQ? The VA study is one, yet there were other studies reported in France, China, Spain that showed positive results. Millions of people have been using HCQ for decades with no ill effects. IIRC, the risks were only people with weak hearts and already in later stages of being very sick. We will just have to agree to disagree on this one Lifts.
The studies proved HCQ ineffective, as for France they stopped all studies because HCQ was killing study subjects. No need to agree Hank.
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Old 06-01-2020, 01:57 PM   #11
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France Bars Use Of Hydroxychloroquine In COVID-19 Cases

May 27, 202012:39 PM ET

Bill Chappell
Twitter

The move comes after the World Health Organization halted clinical trials of the drug as a treatment, citing a study that found no benefit and a higher mortality rate for hospitalized patients. A box of hydroxychloroquine, under the brand name Plaquenil, is seen in a pharmacy in Paris.
Chesnot/Getty Images

The French government is revoking a decree that had allowed hospitals to prescribe hydroxychloroquine in some COVID-19 cases, saying there is no proof that it helps patients — and citing data that shows it could cause heart problems and other health risks.

"This molecule must not be prescribed for patients affected by COVID-19," the Ministry of Solidarity and Health said as it announced the change.

The move to bar hospitals from prescribing the drug for coronavirus patients comes two days after the World Health Organization halted clinical trials of hydroxychloroquine as a treatment for COVID-19. The WHO cited a study published in The Lancet, that had found no benefit from the drug and reported a higher mortality rate for hospitalized patients and "an increased frequency of ventricular arrhythmias."

France's health ministry had approved hydroxychloroquine for emergency prescriptions in COVID-19 cases in late March.

As France 24 reports, that's when French researcher Didier Raoult, who has been an insistent proponent of hydroxychloroquine, said he had successfully treated COVID-19 patients using the controversial drug in combination with azithromycin. But the health ministry says recent studies show the treatment can produce "cardiac toxicity, particularly in combination with azithromycin."
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Researchers continue to evaluate the possible use of hydroxychloroquine, which is used to treat malaria and lupus, to fight the coronavirus, with at least two studies underway in the U.S. As NPR's Joe Palca reports, the drug has been found to be able to prevent replication of the coronavirus.

President Trump has frequently touted hydroxychloroquine as a treatment for COVID-19 — and last week, he said that he was taking doses of both hydroxychloroquine and zinc to protect against the coronavirus, despite warnings about the drug.

"I've taken it for about a week and a half now. And I'm still here," he said.

Both the Food and Drug Administration and the National Institutes of Health have warned of health risks involved with people taking hydroxychloroquine hoping to prevent or treat COVID-19.

On the same day Trump said he was taking the drug, the FDA issued a list of its potentially dangerous side effects:

"Side effects of hydroxychloroquine include irreversible retinal damage, cardiac effects (including cardiomyopathy and QT prolongation), worsening of psoriasis and porphyria, proximal myopathy and neuropathy, neuropsychiatric events, and hypoglycemia."
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Old 06-01-2020, 02:06 PM   #12
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French study finds hydroxychloroquine doesn't help patients with coronavirus

By Dr. Minali Nigam and Elizabeth Cohen,

In the French study, doctors looked back at medical records for 181 patients with Covid-19 who had pneumonia and required supplemental oxygen. About half had taken hydroxychloroquine within 48 hours of being admitted to the hospital, and the other half had not.

The doctors followed the patients and found there was no statistically significant difference in the death rates of the two groups, or their chances of being admitted to the intensive care unit.
The study also raised important safety concerns about hydroxychloroquine.
In the study, eight patients who took the drug developed abnormal heart rhythms and had to stop taking it.
Abnormal heart rhythms are a known side effect of hydroxychloroquine, which has been used for decades to treat patients with diseases such as malaria, lupus and rheumatoid arthritis.
Doctors in Sweden and Brazil have sounded warnings about chloroquine, a very similar drug, because of heart problems.
In the new study, among the 84 patients who took hydroxychloroquine, 20.2% were admitted to the ICU or died within seven days of taking the drug. Among the 97 patients who did not take the drug, 22.1% went to the ICU or died.
The difference was not determined to be statistically different



Looking just at deaths, 2.8% of the patients who took hydroxychloroquine died, and 4.6% of the patients who did not take it died. That difference was also not found to be statistically significant.

"These results do not support the use of [hydroxychloroquine] in patients hospitalised for documented SARSCoV-2-positive hypoxic pneumonia," the study authors wrote.
The study was published Tuesday on medRxiv.org, a pre-print server founded by Yale University, the journal BMJ and Cold Spring Harbor Laboratory.
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Old 06-01-2020, 02:14 PM   #13
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Clinical Trial in China Says Malaria Drug Doesn’t Help COVID-19

Published: Apr 15, 2020 By Mark Terry

Coronavirus

Evidence is accumulating that chloroquine and hydroxychloroquine, drugs traditionally used to treat malaria as well as rheumatoid arthritis and lupus, might not be effective in treating COVID-19, the disease caused by the novel coronavirus. A study out of China in 150 hospitalized patients conducted at 16 sites showed that hydroxychloroquine did not help patients clear the virus better than standard care.

On March 30, the U.S. Food and Drug Administration (FDA) approved the use of the drug under an Emergency Use Authorization (EUA). This allowed for the drugs to be “donated to the Strategic National Stockpile to be distributed and prescribed by doctors to hospitalized teen and adult patients with COVID-19, as appropriate, when a clinical trial is not available or feasible.”

Sandoz, a division of Novartis, donated 30 million doses of hydroxychloroquine to the stockpile and Bayer donated 1 million doses of chloroquine.

President Trump heralded the drug as a “game-changer” despite skepticism from some physicians and researchers, including Anthony Fauci, director of the U.S. National Institute of Allergy and Infectious Disease (NIAID).

Of the recent study, Allen Cheng, an infectious diseases physician and professor of epidemiology at Melbourne’s Monash University, told MSN, “When testing new treatments, we are looking for signals that show that they might be effective before proceeding to larger studies. This study doesn’t show any signal, so it is probably unlikely that it will be of clinical benefit.”

The patients did show a decrease in C-reactive protein, a measurement of inflammation. In the 75 patients who took hydroxychloroquine, there were more side effects, but they were mostly mild, with diarrhea being the most common. Wei Tang of Ruijim Hospital in Shanghai, who led the research, suggested the drugs’ anti-inflammatory effects probably helped with the patients’ symptoms.

This follows news that a small trial in Brazil testing chloroquine for COVID-19 was halted after patients taking the higher doses developed irregular heart rates that increased the risk of possibly fatal arrhythmias. That study examined 81 hospitalized patients in Manaus, Brazil and was sponsored by the Brazilian state of Amazonas. The trial had no controls because the drug was on the country’s national guidelines recommending use of the drug in COVID-19 patients. Patients in the trial also received the antibiotic azithromycin (Z-Pak), which also has some cardiac risk.

“To me, this study conveys one useful piece of information, which is that chloroquine causes a dose-dependent increase in an abnormality in the ECG that could predispose people to sudden cardiac death,” David Juurlink, an internist and head of the division of clinical pharmacology at the University of Toronto, told The New York Times.

One of the Brazilian researchers, Marcus Lacerda, in an email to The New York Times, said the trial found that “the high dosage that the Chinese were using is very toxic and kills more patients. That is the reason this arm of the study was halted early.”

Bushra Mina, section chief of pulmonary medicine at Lenox Hill Hospital in Manhattan, told The Times that the trial data probably wouldn’t change his hospital from prescribing a five-day course of hydroxychloroquine and azithromycin to hospital patients who were not severely ill. The patients are monitored closely and the dosing is halted if any heart abnormalities are observed. “If you’re going to use it because you have no alternative, then use it cautiously,” he said.

These studies and other data appear to be shifting most physicians’ use of the drugs away from treatment for COVID-19. David Gorski, who the Los Angeles Times refers to as a “veteran pseudoscience debunker at Wayne State University Medical School” in Detroit, said “the evidence that hydroxychloroquine, chloroquine, or the hydroxychloroquine/azithromycin combination is an effective treatment for COVID-19 is getting weaker with every publication.”

Vineet Chopra, head of hospital medicine at the University of Michigan, said on April 2, “We haven’t seen any clear evidence of benefit so we aren’t going to use hydroxychloroquine routinely anymore. That’s based upon the fact that we’ve been prescribing hydroxychloroquine for a few weeks, did not see therapeutic benefit, but did see adverse effects.”
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Old 06-01-2020, 02:29 PM   #14
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May 27, 2020 / 11:48 PM / 5 days ago
EU governments ban malaria drug for COVID-19, trial paused as safety fears grow
Matthias Blamont, Alistair Smout, Emilio Parodi

4 Min Read

PARIS/LONDON/MILAN (Reuters) - European governments moved on Wednesday to halt the use of anti-malaria drug hydroxychloroquine to treat COVID-19 patients, and a second global trial was suspended, further blows to hopes for a treatment promoted by U.S. President Donald Trump.

The moves by France, Italy and Belgium followed a World Health Organization decision on Monday to pause a large trial of hydroxychloroquine due to safety concerns.

A UK regulator said on Wednesday that a separate trial was also being put on hold, less than a week after it started. The study, being led by the University of Oxford and partly funded by the Bill and Melinda Gates Foundation, was expected to involve as many as 40,000 healthcare workers.

“All hydroxychloroquine trials in COVID-19 remain under close review” while investigators assess any further risks, the Medicines and Healthcare products Regulatory Agency (MHRA) said in an email to Reuters.

The swift moves by authorities in countries hit hardest by the pandemic highlighted the challenge for governments scrambling to find ways to treat patients and control the novel coronavirus.

After early reports that it might help some patients, regulators in several countries had allowed hydroxychloroquine to be used as a potential COVID-19 treatment.

Trump was a particularly strong supporter, describing the drug as a “gamechanger.” He later announced he was taking it to prevent infection.

However, more recent studies have raised serious safety issues. British medical journal The Lancet has reported coronavirus patients receiving hydroxychloroquine were more likely to die and experience dangerous irregular heartbeats.
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Old 06-01-2020, 02:31 PM   #15
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CORONAVIRUS RESEARCH
Experts pour doubt on hydroxychloroquine study that saw WHO ban use for Covid-19

Issued on: 30/05/2020 - 14:55Modified: 30/05/2020 - 14:55
The World Health Organisation has suspended clinical trials with hydroxychloroquine in several countries.


More than 100 scientists have raised concerns over a influential study of hydroxychloroquine and chloroquine that led the World Health Organisation to suspend clinical trials to determine if the drugs could be an effective treatment for Covid-19.
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Published last week in The Lancet, the large-scale study suggested the malaria drugs could be dangerous to people with severe cases of Covid-19, increasing the risk of abnormal heart rhythms and even death.

Now, scientists across the world are asking the research team, led by Harvard professor Dr Mandeep Mehra, to release its data for further analysis and independent academic review.
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