How to increase collegen synthesis!! (i.e. - strengthen those tendons and ligiments)

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  • Easto

    How to increase collegen synthesis!! (i.e. - strengthen those tendons and ligiments)

    originally posted by AnimalMass on competitivemuscle.com

    While injecting test increases protein syntesis by roughly 50 times, depending on dose and time, most bodybuilders forget that it will reduce collagen synthesis by more than 50% -- more like 80%, giving you the collagen synthesis rate of a senior citizen. Since collagen makes up tendons, bros are very prone to injury if they continue to lift very heavy, unless they cycle off T and let their collagen synthesis get back to normal. It's like having the skeletal muscle of a gorilla with the tendons of a very old man.

    Winstrol increases collagen synthesis. It will give you bigger tendons. However, your body compensates for this by making them more brittle, weaker, and more prone to injury. I can't tell you how many bros work out anaerobically and become injured while on winstrol. Guys who lift in the 1-5 rep range while on winstrol, to baseball players who sprint all out from a stationary position -- winstrol should be the LAST drug they choose. Most of them like winstrol because they don't get the weight gain from it but it is very detrimental to bros who train for any sport anaerobically. Tendons tear easily on it.

    Also, the drugs I mention increase collagen syn while also increasing collagen cross-linking integrity, making for a much stronger tendon.

    Winstrol, on the other hand, will dramatically increase collagen syn, but ironically it decreases collagen cross-linking integrity, thus making a much weaker tendon.

    You can plan a cycle of AAS which will increase collagen synthesis and skeletal muscle growth at the same time. The key is the drug(s) you choose.

    Deca, Equipoise, Anavar, and Primobolan will ALL increase skeletal muscle while at the same time dramatically increase collagen syn and bone mass and density, leaving you with a substantially reduced chance of becoming injured than if you choose to use AAS like sus, cyp, or enth.

    While testosterone will increase bone mass and density, even at supra-physiological levels, the result is weaker tendons due to inhibition of collagen syn.

    To plan a cycle where the goal is to increase skeletal muscle mass/strength while at the same time increase joint/tendon/ligament strength, enough to keep up with the dramatic increase in skeletal muscle, you must choose drugs like Eq, Deca, Anavar, or Primo as the base of your cycle. Testosterone and its esters can be added to your cycle to keep levels within a 'normal' physiological range (ie, 100-200 mg/wk) but must not go above this. Since drugs like eq, deca, anavar and primo will reduce endogenous, natural levels of test, these levels may be maintained with exogenous test in the 100-200 mg/wk range. Test at this dose will not inhibit collagen syn, but paradoxically, will help increase it. It is when exogenous testosterone is used > 200 mg/wk that collagen syn is inhibited.

    Deca @ 3 mg/kg a week(about 270 mg/wk for a 200 lb male) will increase procollagen III levels by 270% by week 2. Procollagen III is a primary indicator used to determine the rate of collagen syn. As you can see, deca is a very good drug at giving you everything you want -- an increase in collagen syn, an increase in skeletal muscle, and increases in bone mass and density. The one thing it does not give you is wood

    Primobolan, @ 5 mg/kg, will increase collagen synthesis by roughly 180% -- less than deca and equipoise but still substantial.

    Equipoise @ 3 mg/kg will increase procollagen III by approximately 340% -- slightly better than deca.

    Oxandrolone has over a hundred studies documenting its effectiveness at treating patients needing rapid increases in collagen syn to enhance healing.

    These drugs have longer half-lives than most other AAS, so this should be considered when timing your post cycle clomid use. Here they are:

    Deca: 15 days Equipoise: 14 days Primobolan: 10.5 days

    Anavar has a half-life of only 8 hours so it should not pose a problem.

    GH is probably the most remarkable drug at increasing collagen synthesis. It increases collagen syn in a dose dependant manner -- the more you use, the more you will increase collagen syn. It has also demonstrated this ability in short and long term studies. From what I've read, hGH at 6 iu/day increased the collagen deposition rate by around 250% in damaged collagen structures. This result indicates that the increased biomechanical strength of wounds to collagen structures treated with biosynthetic human growth hormone was produced by an increased deposition of collagen in the collagen structures.

    Eq, primo, anavar, and deca are all good -- they increase several biomakers of collagen syn -- ie, type III, II, I, procollagen markers. GH just seems to do so most dramatically.

    Use of any of these drugs @ supra-physiological levels with a maintenance dose of test will increase collagen syn while at the same time increase skeletal muscle mass. Skeletal muscle mass gains will not be as dramatic as with large testosterone doses but you have to weigh the risk/reward basis for yourself. Also, these drugs do not satisfy the libido like testosterone, but that is not the point of this thread. It is only to demonstrate that you can increase skeletal muscle and collagen syn at the same time with certain AAS -- the decision is up to you.

    AnimalMass
  • liftsiron
    Administrator
    • Nov 2003
    • 18443

    #2
    Very good read!!!!!
    ADMIN/OWNER@Peak-Muscle

    Comment

    • rado

      #3
      I knew I liked AS for a reason, thanks !

      Comment

      • house1

        #4
        great post brother

        Comment

        • Andre_G

          #5
          Good post Easto. Im glad i read that. I would have probably used winny in the future and i lift for strength (1-6 reps)

          Alot of AAS were not listed, does that mean they shouldn't pose any problems? Fina for example?
          Last edited by Guest; 12-05-2003, 07:52 PM.

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          • Andre_G

            #6
            bump

            This is a good read, anyone else have any comments?

            What about Fina?

            Comment

            • workingout
              VET
              • Apr 2004
              • 455

              #7
              When it says "Equipoise @ 3 mg/kg will increase procollagen III by approximately 340% -- slightly better than deca." is that a one time dose or is that the base of a weekly cycle? If a cycle...How many weeks? anyone know?

              OR
              "Deca @ 3 mg/kg a week(about 270 mg/wk for a 200 lb male) will increase procollagen III levels by 270% by week 2." Could a person run one two week cycle every three months?

              What type of natty test shut down could be expected from running test at 100-200mgs a week vs the gains in mussle mass and collagen syn?

              I ask about these things cuz I am very concerned about weight gain. I'm a fighter and have to keep weight classes in mind, but still looking to gain an advantage in str, and healing time.
              He who does not strike first is the first stricken.

              BS ESS

              Comment

              • liftsiron
                Administrator
                • Nov 2003
                • 18443

                #8
                Originally posted by workingout
                When it says "Equipoise @ 3 mg/kg will increase procollagen III by approximately 340% -- slightly better than deca." is that a one time dose or is that the base of a weekly cycle? If a cycle...How many weeks? anyone know?

                OR
                "Deca @ 3 mg/kg a week(about 270 mg/wk for a 200 lb male) will increase procollagen III levels by 270% by week 2." Could a person run one two week cycle every three months?

                What type of natty test shut down could be expected from running test at 100-200mgs a week vs the gains in mussle mass and collagen syn?

                I ask about these things cuz I am very concerned about weight gain. I'm a fighter and have to keep weight classes in mind, but still looking to gain an advantage in str, and healing time.



                To repair conective tissue, I would run either EQ or deca at least 12 weeks, I'm basing that on personal experience.


                "What type of natty test shut down could be expected from running test at 100-200mgs a week vs the gains in mussle mass and collagen syn?"

                I don't fully understand this question, but you can probably expect near total htpa shutdown from 200mgs test/week.
                ADMIN/OWNER@Peak-Muscle

                Comment

                • workingout
                  VET
                  • Apr 2004
                  • 455

                  #9
                  Lifts>> that's a perfect answer...that is what I was afraid of. If I'm not mistaken, running test at that low of a dose isn't gonna do squat for strgenth and mass gains, but it would allow you to still reap the benifits of increased collegan synthesis.

                  So I would get the negatives of running test, at that low of a dose, without any of the beniffits, except for the disruption of collagen synthesis...Right?
                  He who does not strike first is the first stricken.

                  BS ESS

                  Comment

                  • liftsiron
                    Administrator
                    • Nov 2003
                    • 18443

                    #10
                    Originally posted by workingout
                    Lifts>> that's a perfect answer...that is what I was afraid of.

                    So I would get the negatives of running test, at that low of a dose, without any of the beniffits, except for the disruption of collagen synthesis...Right?

                    I think that your refering to this statement
                    "While testosterone will increase bone mass and density, even at supra-physiological levels, the result is weaker tendons due to inhibition of collagen syn. "

                    This i believe only happens after test is ran for a quite long peroid of time without deca, EQ, or primo. A 12 week cycle of test at 500mgs iimo will not be to disruptive to collagen syn. But will bill alot srength and a fair amount of size. Remember in steroid use, it is never all or nothing, but varying degrees of various effects.
                    ADMIN/OWNER@Peak-Muscle

                    Comment

                    • workingout
                      VET
                      • Apr 2004
                      • 455

                      #11
                      Lifts or anyone else>>So this possible cycle, in your opinion, will not interfere with collagn synthesis.

                      week substance Dose
                      1-16.............Test..............600mg
                      2-14..............EQ...............600mg
                      7-14..............tren.............225mg

                      how's that for following your advice?
                      He who does not strike first is the first stricken.

                      BS ESS

                      Comment

                      • workingout
                        VET
                        • Apr 2004
                        • 455

                        #12
                        Originally posted by Andre_G
                        bump

                        This is a good read, anyone else have any comments?

                        What about Fina?
                        Just a guess from a person who dont know jack. But it seems that the things that dry/lean you out are more injurous. Thats why I stoped taking Halo when I sprained my hip, I wanted to put some fat back on. Therefore, Finna would not be the best choice for Collagen Synthesis. But like I said this is just a poor guess based on what little I know.

                        I would wecome a more knowlegable opinion on this.
                        He who does not strike first is the first stricken.

                        BS ESS

                        Comment

                        • FContact
                          Registered User
                          • Oct 2003
                          • 1332

                          #13
                          I posted this to a member here once but never thought of making it a thread, good thinking Easto.


                          Disclaimer: PremierMuscle and FContact do not promote the use of anabolic steroids without a doctor's prescription. The information we share is for entertainment purposes only.

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