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Urology. 2017 Jul 31. pii: S0090-4295(17)30777-X. doi: 10.1016/j.urology.2017.07.030. [Epub ahead of print]
Cardiovascular Health, Erectile Dysfunction, and Testosterone Replacement: Controversies and Correlations.
Elkhoury FF1, Rambhatla A2, Mills JN3, Rajfer J3.
Author information
Abstract
Erectile dysfunction (ED) and cardiovascular disease (CVD) share a similar underlying pathophysiology, and low serum testosterone, known as hypogonadism, is a significant player in both conditions. Hypogonadism is a known risk factor for cardiovascular events and worsened mortality, thus influencing physicians to recommend testosterone replacement in such patients. However, at least four recent reports suggest that testosterone replacement may worsen cardiovascular risk, heightening hesitancy in the medical community to treat hypogonadal men with testosterone. This review highlights the triad of CVD, ED, and testosterone therapy and provides the physician with some guiding principles to navigate these recent concerns.
Copyright © 2017 Elsevier Inc. All rights reserved.
KEYWORDS:
cardiovascular disease; coronary artery disease; erectile dysfunction; hypogonadism; testosterone
Cardiovascular Health, Erectile Dysfunction, and Testosterone Replacement: Controversies and Correlations.
Elkhoury FF1, Rambhatla A2, Mills JN3, Rajfer J3.
Author information
Abstract
Erectile dysfunction (ED) and cardiovascular disease (CVD) share a similar underlying pathophysiology, and low serum testosterone, known as hypogonadism, is a significant player in both conditions. Hypogonadism is a known risk factor for cardiovascular events and worsened mortality, thus influencing physicians to recommend testosterone replacement in such patients. However, at least four recent reports suggest that testosterone replacement may worsen cardiovascular risk, heightening hesitancy in the medical community to treat hypogonadal men with testosterone. This review highlights the triad of CVD, ED, and testosterone therapy and provides the physician with some guiding principles to navigate these recent concerns.
Copyright © 2017 Elsevier Inc. All rights reserved.
KEYWORDS:
cardiovascular disease; coronary artery disease; erectile dysfunction; hypogonadism; testosterone