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Old 02-14-2019, 12:51 PM   #16
liftsiron
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On a few boards that even bothered to cite the study, this is the one I found. I don't know how this would relate to adult human bodybuilders.


US National Library of Medicine
National Institutes of Health

Journal ListBioengineeredv.8(1); 2017PMC5172501

Logo of bioengineered
Bioengineered. 2017; 8(1): 14–20.
Published online 2016 Oct 28. doi: 10.1080/21655979.2016.1227141
PMCID: PMC5172501
PMID: 27791460
Effect of testosterone on the proliferation and collagen synthesis of cardiac fibroblasts induced by angiotensin II in neonatal rat
Xiaocun Yang,a Ying Wang,a Shuxun Yan,b Lina Sun,a Guojie Yang,a Yuan Li,a and Chaonan Yua
Author information Article notes Copyright and License information Disclaimer
This article has been cited by other articles in PMC.

ABSTRACT

The objective is to explore the effect of testosterone on the proliferation and collagen synthesis of neonatal rat cardiac fibroblasts (CF) induced by Angiotensin II (Ang II) and the underlying mechanisms. Derived from neonatal rats, the CFs were divided into 4 groups: the control group, Ang II group, testosterone group, and testosterone + Ang II group in vitro. Cell cycle distribution, collagen counts, and phosphorylated extracellular signal-regulated kinase (ERK1/2) (p - ERK1/2) expression were assessed by flow cytometry, VG staining, and immunocytochemistry, respectively. The Ang II group had a much higher proportion of cells in the S-phase, higher collagen contents, and a higher p - ERK1/2 expression level than either the control or testosterone group. However, these factors were significantly reduced in the testosterone + Ang II group as compared to the Ang II group. In terms of cells in the S-phase and the collagen contents, there was not a significant difference between the testosterone group and the control. However, the protein expression of p-ERK1/2 was significantly increased in the testosterone group as compared to the control. Testosterone inhibits the proliferation and collagen synthesis of CF induced by Ang II. The underlying mechanism may involve the ERK1/2 signaling pathway.
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Old 02-14-2019, 01:01 PM   #17
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Originally Posted by warreng View Post
I guess I'm wondering what the odds of this injury healing of its own accord are? I don't know whether it's a full or partial tear, but I can't extend my leg from a seated position. If, say, I don't get surgery, will I recover full use of my leg? Usually, the body knows something is wrong and begins to heal itself. Is that the case here?

And should I run a higher dose of gh? I know that helps with injuries, but will it help with this one? Sorry for all the questions but I am trying to gain a better understanding of my predicament while waiting for the ortho to whom I was referred to get in touch.


I don't think that can be answered at this point. Only time will tell bro. Go to the hospital.
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Old 02-14-2019, 01:37 PM   #18
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Drop you gear down to trt, use gh and get your surgery done promptly.
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Old 02-14-2019, 04:13 PM   #19
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Get that looked at asap dude. I had a friend (RIP) who tore BOTH of his quads where they attached to the knees doing squats 10 years ago. I wasn't there when it happened, but the owner was and seen it. He went down like a sack of bricks. And guess what - he literally got up and hobbled out of the gym on his own, and drove to the ER. Others offered to give him a ride, but he refused. They did surgery to re-attach. My point is, don't use the " still can walk" gig as a barometer to gauge the severity of your injury. Btw he was running test and tren, both high dose, and he didn't say shit to the docs about being on gear due to insurance purposes.
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Old 02-16-2019, 12:18 PM   #20
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What if the doc asks about gear? Worried both because, for insurance purposes, it's not good to have that notated on your medical records, and also because I wonder whether it could interfere with surgery.,
I was up front with my ortho on my shoulder surgeries about my anabolic use. Nothing ever changed with my insurance or anything. It's completely confidential.
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Old 02-16-2019, 12:23 PM   #21
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I read the paperwork when I saw the Ortho shoulder specialist and one of the required signatures allowed all records to be released to the insurance provider. I don't trust the docs or the insurance companies. Often one hand washes the other.
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Old 02-16-2019, 02:10 PM   #22
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Originally Posted by warreng View Post
Thanks dead and SJ - I've been to two docs en route to getting an ortho but have not been able to see one yet. Keep getting cancelled on, appointments further out, even an MRI, etc. Still can't walk or extend my leg and I keep reading that it can be serious if not treated quickly. Very irritated.
ER?
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Old 02-16-2019, 05:17 PM   #23
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Unfortunately, ERs don't normally do MRIs unless it's more of a life or death situation. I ruptured my left triceps a few years ago, while at work. Went straight to the ER where they did the standard x-rays that only showed that no bones were broken. They gave me a referral to a specialist and was in their office in 2 days, an MRI the day after and surgery within 7 days of my initial injury.
I always tell people, you MUST be your own advocate when it comes to your healthcare and treatment.
best of luck to you and I wish you a speedy recovery.
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Old 02-16-2019, 05:26 PM   #24
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Just general reference for anyone with a torn/ ruptured muscle or tendon, go directly to ortho and tell them what happened. 9/10 they will work you in, order an mri and then call to schedule surgery within a few days. Sometimes they’ll schedule surgery while you’re in the office and still order the mri just so the doc knows exactly what he’s working with. Many good ortho docs can tell just through some mechanical movement and palpating what is going on. An ER visit will always be a waist of time in this type of scenario and you’ll often get proper treatment quicker, believe it or not, by NOT going to the ER
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Old 02-17-2019, 04:49 PM   #25
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That’s some bullshit man. I’m wondering if U should wait for after the surgery to start The hgh. May not want it to start healing while it’s fucked up. May heal wrong and then your screwed when they go in to fix it. I’m just speculating hear. Something to consider.
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Old 02-19-2019, 05:32 PM   #26
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I'm just as lost as you on this my friend. I feel like you should start a log once you figure out what you're gonna do for recovery work.
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Old 02-19-2019, 08:15 PM   #27
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So how bad did the ortho say it is? Hopefully they will brace it somehow and u can use crutches to get around. Any idea how long the recovery will be?
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