Nolva/Clomid - Why Both?

[Blown_SC]

Nolva is the dominating SERM in pct. Both nolva and clomid are SERMS but tissue specific or selective to certain areas. The case of clomid v nolva is clomid is a weak anti-estrogen blocker as opposed to nolvadex but clomid is needed to stimulate LH levels back to normal thus it's specific use. Nolvadex is selective in this aspect that it's main purpose as studies show is a weak estrogen and binds to receptors during PCT.

Nolvadex is needed for what I call the estrogen back lash one will recieve during the off time right after a cycle. When androgen levels drop estrogen flushs the receptors and nolvadex is needed. To not hinder gains or keep them longer, it is suggestable to restore the balance as quick as possible. Clomid is suggestable for this even though clomid is an anti-estrogen as well this is shown to be not it's selection.

To conclude, both SERMS are neccessary for proper restoration and serve both purposes needed in PCT. One, clomid to restore LH levels back to normal. Two, nolvadex to act as the anti-estrogen and block the flush.


Posted by LMR @ IFL...

[Deacon]

I prefer to use both for PCT

[liftsiron]

I personally don't believe that clomid is needed as nolvadex just works better all around. Here is a long often heated but very worthwhile thread.

http://www.intense-training.com/forums/showthread.php?t=19687&highlight=nolvadex

[liftsiron]

If you don't want to read the entire thing here is a good study comparing the two.


Hormonal effects of an antiestrogen, tamoxifen, in normal and oligospermic men.

Vermeulen A, Comhaire F.

The administration of tamoxifen, 20 mg/day for 10 days, to normal males produced a moderate increase in luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, and estradiol levels, comparable to the effect of 150 mg of clomiphene citrate (Clomid). However, whereas Clomid produced a decrease in the LH response to LH-releasing hormone (LHRH), no such effect was seen after the administration of tamoxifen. In fact, prolonged treatment (6 weeks) with tamoxifen significantly increased the LH response to LHRL. Treatment of patients with "idiopathic" oligospermia for 6 to 9 months resulted in a significant increase in gonadotropin, testosterone, and estradiol levels. A significant increase in sperm density was observed only in subjects with oligospermia below 20 X 10(6)/ml and normal basal FSH levels. When basal FSH levels were increased or oligospermia was moderate (greater than 20 X 10(6)/ml); no effect on sperm density was seen. As sperm density increased, FSH levels decreased, suggesting an inhibin effect. Sperm motility was not improved by tamoxifen treatment. In five boys with delayed puberty, tamoxifen treatment appeared to activate the pituitary-gonadal axis and pubertal development.

http://anabolicminds.com/forum/arch...hp/t-16973.html