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12-21-2008, 01:48 PM | #1 |
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Test flu.
Etiocholanolone is believed to produce fever and flu-like aches and pains because it induces the systemic release of Interleukin-1, a powerful proinflammatory cytokine:
Pyrogenicity of etiocholanolone and interleukin-1 in New and Old World Monkeys. Steinetz BG, Randolph C, Werner R, Mahoney CJ. New York University Medical Center, Laboratory for Experimental Medicine and Surgery in Primates, Tuxedo 10987, USA. steinetz@charlotte.med.nyu.edu Etiocholanolone (5beta-androstan-3alpha-ol-17-one; designated E) is one of the major products of metabolism of testosterone and androstenedione (androst-4-ene-3,17-dione) in many mammalian species, including humans. E and several other 5beta-reduced steroids have been found to induce fever in humans. The pyrogenic effect of these steroids has been shown to be due to the release of interleukin-1 (IL-1) from the leukocytes that are mobilized in response to the steroid injections. Old World Monkeys such as Rhesus monkeys (Macaca mu/atta), metabolize androgens similarly to humans, and E is a normal metabolite. However, New World Monkeys such as Squirrel monkeys (Saimiri sciureus), lack hepatic 5alpha- and 5beta-steroid reductases and excrete androgens primarily in an unaltered state; E is not produced. Therefore, we postulate that Squirrel monkeys likewise may have lost the ability to respond to 17-ketosteroids such as E. To test this hypothesis, adult male Rhesus and Squirrel monkeys were treated with E, and their rectal temperatures were recorded over a 24-hr period. Rhesus monkeys exhibited a rise of up to 3 degrees F following E injection. Squirrel monkeys, on the other hand, did not exhibit any increase in rectal temperature over the 24-hr period, even when doses up to 250 times the effective human dose were used. However, both species responded to injected IL-1alpha with a robust increase in rectal temperature. The data show that E is pyrogenic in Rhesus, but not Squirrel monkeys. The findings support the notion that injected E may induce release of IL-1 in Rhesus monkeys, but not in Squirrel monkeys.
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12-21-2008, 02:55 PM | #2 |
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GOod read, all those Test monkeys..
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12-21-2008, 03:35 PM | #3 |
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12-22-2008, 09:57 AM | #4 |
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12-22-2008, 10:34 AM | #5 |
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I think high BA levels can cause localized heat in the area of injection. Also many UG labs are way overdosed.
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12-22-2008, 11:13 AM | #6 |
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12-22-2008, 11:46 AM | #7 |
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Could also be an allergic reaction to other ingredients in UG gear to.
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12-22-2008, 11:49 AM | #8 |
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makes you wonder what in the hell they are adding in there....
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12-25-2008, 05:40 PM | #9 | |
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wonder what long term exposure to metals can cause health wise |
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12-26-2008, 06:20 AM | #10 | |
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Please list the UG's with metals and source of reference if possible. Heavy metals like lead and mercury can cause extreme problems especially withing the CNS, insanity among other milder problems such as memory loss, coordination, auditory and visual hallucinations, psychosis, etc. lol, remember the saying "mad as a hatter" hat makers often went insane because of exposure to small amounts of mercury over a length of time.
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12-26-2008, 08:48 AM | #11 | |
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12-26-2008, 09:27 AM | #12 |
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Trouble with mags like MD and muscle mag is that often they lie through their teeth.
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12-29-2008, 09:56 AM | #13 |
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I think ms wetback posted the lab results, not 100% sure it was her though.
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05-15-2018, 05:41 PM | #14 |
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Bump.
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08-07-2018, 12:41 PM | #15 |
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Worth another look at.
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