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Review
J Clin Aesthet Dermatol
. 2019 May;12(5):20-26.
Epub 2019 May 1.
The Potential Uses of N-acetylcysteine in Dermatology: A Review
Monica Janeczek 1 , Lauren Moy 1 , Alexandria Riopelle 1 , Olivia Vetter 1 , Jeave Reserva 1 , Rebecca Tung 1 , James Swan 1
Affiliations
PMID: 31320973 PMCID: PMC6561714
Free PMC article
Abstract
Background: In recent studies, N-acetylcysteine has been shown to be efficacious in several dermatologic conditions. Objective: The aim was to review clinical trials that assess the efficacy of N-acetylcysteine in cutaneous disorders. Design: The PubMed database was searched and a manual search of clinical trials in the references was performed. Studies included randomized, controlled studies, uncontrolled studies, meta-analyses, and systemic reviews published between years 1966 and 2017. Results: Efficacy of N-acetylcysteine was shown in excoriation disorder, onychophagia disorder, trichotillomania, acne vulgaris, Type I lamellar ichthyosis, bullous morphea, systemic sclerosis, toxic epidermal necrolysis, atopic dermatitis, xeroderma pigmentosum, and pseudoporphyria. Studies also show benefits in wound healing and photoprotection. Conclusion: The review of available literature suggests that N-acetylcysteine could potentially serve as a safe, tolerable, and effective therapeutic option for a variety of dermatologic conditions.
Keywords: N-acetylcysteine; dermatological disorder; intravenous therapy; oral therapy; pharmacology; topical therapy.
Review
J Clin Aesthet Dermatol
. 2019 May;12(5):20-26.
Epub 2019 May 1.
The Potential Uses of N-acetylcysteine in Dermatology: A Review
Monica Janeczek 1 , Lauren Moy 1 , Alexandria Riopelle 1 , Olivia Vetter 1 , Jeave Reserva 1 , Rebecca Tung 1 , James Swan 1
Affiliations
PMID: 31320973 PMCID: PMC6561714
Free PMC article
Abstract
Background: In recent studies, N-acetylcysteine has been shown to be efficacious in several dermatologic conditions. Objective: The aim was to review clinical trials that assess the efficacy of N-acetylcysteine in cutaneous disorders. Design: The PubMed database was searched and a manual search of clinical trials in the references was performed. Studies included randomized, controlled studies, uncontrolled studies, meta-analyses, and systemic reviews published between years 1966 and 2017. Results: Efficacy of N-acetylcysteine was shown in excoriation disorder, onychophagia disorder, trichotillomania, acne vulgaris, Type I lamellar ichthyosis, bullous morphea, systemic sclerosis, toxic epidermal necrolysis, atopic dermatitis, xeroderma pigmentosum, and pseudoporphyria. Studies also show benefits in wound healing and photoprotection. Conclusion: The review of available literature suggests that N-acetylcysteine could potentially serve as a safe, tolerable, and effective therapeutic option for a variety of dermatologic conditions.
Keywords: N-acetylcysteine; dermatological disorder; intravenous therapy; oral therapy; pharmacology; topical therapy.