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Go Back   Peak-Muscle.com > Anabolic Steroid Discussion > HGH, IGF-1, Insulin and Thyroid
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Old 09-18-2018, 04:48 PM   #1
ESTROGEN GUY
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HGH ONCE A DAY OR TWICE (STUDY)

Clin Endocrinol (Oxf). 1994 Sep;41(3):337-43.
Metabolic effects of growth hormone administered subcutaneously once or twice daily to growth hormone deficient adults.
Laursen T1, Jørgensen JO, Christiansen JS.
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Abstract
OBJECTIVE:
The aim of this study was to compare the metabolic effects of GH administered subcutaneously either once or twice daily. The actions of GH might depend upon a pulsatile pattern of serum GH. Pulsatile and continuous intravenous delivery of GH, however, induce similar short-term metabolic effects in GH deficient patients. An improved growth response is obtained in GH deficient children when a fixed weekly GH dose is administered by daily subcutaneous injections instead of twice or thrice-weekly intramuscular injections. A more pulsatile pattern and serum GH levels above zero might be achieved by further increasing the injection frequency. Increased daytime GH levels might, however, adversely affect the circadian patterns of metabolic indices, which have been demonstrated to be more successfully reproduced by evening compared with morning GH administration.
DESIGN AND MEASUREMENTS:
In a cross-over study, 8 GH deficient patients (age 16-43 years) were treated with 3 IU/m2/24 h of human GH. The dose was injected in the evening for 4 weeks and for another 4 weeks two-thirds was injected in the evening and one-third in the morning. At the end of each period the patients were admitted to the hospital for 37 hours. Steady-state profiles of GH, IGF-I, IGF binding proteins 1 and 3, insulin, glucose, lipid intermediates and metabolites were obtained following administration of 3 IU/m2 of GH (at 1900 h (one injection) and at 1900 and 0800 h (two injections)).
RESULTS:
Similar mean integrated levels of serum GH (mU/l) were obtained (7.46 +/- 0.84 (one injection) vs 6.46 +/- 0.62 (two injections) (P = 0.15)). Mean levels +/- SEM of serum IGF-I (micrograms/l) were significantly increased (P < 0.01) following two daily GH injections (330.3 +/- 48.1 (one injection) vs 399.1 +/- 53.0 (two injections)). Serum IGFBP-3 levels were not significantly different on the two occasions, while levels of the GH independent IGFBP-1 (micrograms/l) were slightly but significantly lower following twice-daily GH injections (1.61 +/- 0.42 vs 1.13 +/- 0.56, respectively (P < 0.04)). The pattern of IGFBP-1 was opposite to that of insulin. Similar levels of insulin and glucose were obtained with both GH regimens, while levels of non-esterified fatty acids were significantly higher following once-daily GH injection (P < 0.001).
CONCLUSIONS:
Twice-daily GH injections, apart from producing a more physiological serum GH profile, were superior to one injection in increasing serum IGF-I and decreasing IGFBP-1 levels. Both of these changes tend to amplify the effects of the administered GH. Twice-daily injections, however, resulted in lower night-time levels of lipid intermediates.

Last edited by ESTROGEN GUY; 09-18-2018 at 05:42 PM..
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Old 09-19-2018, 08:12 AM   #2
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I liked it best when I did 2-3 times daily. I was doing 7 total so 3/2/2 injections...
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Old 02-25-2019, 03:31 PM   #3
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Once right when you wake up and once before bed.
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Old 02-25-2019, 03:37 PM   #4
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Great read.
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Old 02-25-2019, 03:40 PM   #5
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Quote:
Originally Posted by Strongisland631 View Post
Once right when you wake up and once before bed.
I know when users administer twice daily injections this is most likely the protocol. But I have read that GH injection prior to bed interferes with the body's own secretion GH production.
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Old 02-25-2019, 04:45 PM   #6
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I read a study less that two weeks ago and the conclusion was it made no difference. I will see if I can find it and post it up.

I guess that is why they call it "practicing" medicine.
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Old 02-25-2019, 05:01 PM   #7
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Originally Posted by 01dragonslayer View Post
I know when users administer twice daily injections this is most likely the protocol. But I have read that GH injection prior to bed interferes with the body's own secretion GH production.
It's gonna interfere with it anyway. Your pituitary doesn't secrete it if it's being injected. Same thing as your balls shutting off when you take test. This is why things like ghrp's are important.
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