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Old 11-07-2019, 10:59 AM   #1
johnjuanb1
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2019 Study on the benefits of ANAVAR

Oxandrolone protects against the development of multiorgan failure, modulates the systemic inflammatory response and promotes wound healing during burn injury.
Ahmad A, et al. Burns. 2019.

https://www.ncbi.nlm.nih.gov/m/pubme...=7&from=anavar

Abstract

Oxandrolone is a synthetic oral non-aromatizable testosterone derivative. This drug has been used successfully for several decades to safely treat growth delays in various diseases including Turner's syndrome. Currently the use of oxandrolone is under clinical testing in children with burn injury; the available data indicate that the anabolic steroid increases net muscle protein balance, maintains lean body mass, and reduces intensive care unit stay. Although oxandrolone is already in clinical trials in burn patients, preclinical burn-related studies with oxandrolone - especially those that go beyond muscle-related parameters and focus on burn-associated organ dysfunction, inflammatory response and wound healing - remain to be conducted. In the current project, using a well-characterized murine model of third-degree burn, we have tested the effect of oxandrolone on indices of organ injury, clinical chemistry parameters and plasma levels of inflammatory mediators. In oxandrolone-treated mice (1mg/kg/day for up to 21 days) there was a significant amelioration of burn-induced accumulation of myeloperoxidase levels in heart and lung (but not the liver and kidney) and significantly lower degree of malon dialdehyde accumulation in the liver (but not the heart, lung and kidney). Oxandrolone-treated mice showed a significant attenuation of the burn-induced elevation in circulating alkaline aminotransferase and amylase levels, while blood urea nitrogen and creatinine levels remained unaffected, indicative of protective effects of the anabolic hormone against burn-induced hepatic and pancreatic (but not renal) functional impairment. Multiple burn-induced inflammatory mediators (TNF-α, IL-1α, IL-1β, IL-4, IL-6, IL-10, IL-12, IP-10, G-CSF, GM-CSF and interferon-γ) were significantly lower in the plasma of oxandrolone-treated animals after burn injury than in the plasma of controls subjected to burns. Finally, oxandrolone significantly accelerated burn wound healing. We conclude that oxandrolone improves organ function, modulates the systemic inflammatory response and accelerates wound healing in a murine model of burn injury.

Last edited by johnjuanb1 : 11-07-2019 at 11:47 AM.
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Old 11-07-2019, 01:58 PM   #2
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I usually take studies using murine models with a grain of salt, but it is interesting. Look forward to seeing what others like Glyco, and maybe GG if he sees it (et al) think. I usually only put much value in human models, but hopefully research continues to go from here...usually how it starts.

My biochem is off, but did they mean Alanine Aminotransferase (ALT)? or Alkaline Phosphatase? What is Alkaline Aminotransferase? I'm assuming it is a liver enzyme of sort?

I can't remember the formula for mice dosage conversion to humans....
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Old 11-08-2019, 05:55 AM   #3
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