Peak-Muscle.com  

Welcome to the Peak-Muscle.com forums.

You are currently viewing our boards as a guest which gives you limited access to view most discussions and access our other features. Come join us in on one of the best online fitness communities. We have 16,000 members that are likeminded towards a fitness, bodybuilding lifestyle. Registration is free and only takes but a few minutes. By joining our free community you will have access to communicate privately with other members (PM), respond to polls, upload content and access many other special features. You will be able to create threads to discuss and or create a fitness regimen. Or just bounce ideas off of some very knowledgeable members. So don't miss out. Registration is fast, simple and absolutely free so please, join our community today!

Register FAQ Members List Calendar Arcade Mark Forums Read
Go Back   Peak-Muscle.com > Anabolic Steroid Discussion > Anabolic Steroid Articles and Studies
User Name
Password




Reply
 
Thread Tools Display Modes
Old 03-01-2018, 09:40 AM   #1
liftsiron
Administrator
 
liftsiron's Avatar
 

Join Date: Nov 2003
Location: Cimmeria
Posts: 15,890
liftsiron has much to be proud ofliftsiron has much to be proud ofliftsiron has much to be proud ofliftsiron has much to be proud ofliftsiron has much to be proud ofliftsiron has much to be proud ofliftsiron has much to be proud ofliftsiron has much to be proud ofliftsiron has much to be proud of
Male hormone reverses cell aging in clinical trial

Science News
from research organizations
Male hormone reverses cell aging in clinical trial

Date:
July 25, 2016
Source:
Fundação de Amparo à Pesquisa do Estado de São Paulo
Summary:
Sex hormones can stimulate production of telomerase, an enzyme naturally found in the human organism, new research shows. The strategy was tested in patients with genetic diseases associated with mutations in the gene that codes for this enzyme, such as aplastic anemia and pulmonary fibrosis. The authors say that the results suggest that the approach can combat the damage caused to the organism by telomerase deficiency.
Share:

Abstract illustration. A new study demonstrates the possibility of inducing synthesis of telomerase, the "cellular elixir of youth."


Telomerase, an enzyme naturally found in the human organism, is the closest of all known substances to a "cellular elixir of youth." In a recent study, Brazilian and US researchers show that sex hormones can stimulate production of this enzyme.

The strategy was tested in patients with genetic diseases associated with mutations in the gene that codes for telomerase, such as aplastic anemia and pulmonary fibrosis. The authors say that the results suggest that the approach can combat the damage caused to the organism by telomerase deficiency.

The study was performed by Brazilian researchers in collaboration with colleagues at the National Institutes of Health (NIH) in the US. Among the scientists involved was Rodrigo Calado, a professor at the University of São Paulo's Ribeirão Preto Medical School (FMRP-USP) and a member of the Center for Cell-Based Therapy (CTC), one of the Research, Innovation and Dissemination Centers (RIDCs) supported by FAPESP.

"One of the processes associated with aging is progressive shortening of telomeres, DNA-protecting structures at the ends of chromosomes, like the plastic tips on shoelaces," Calado said. "Each time a cell divides, its telomeres get shorter. Eventually, the cell can't replicate anymore and dies or becomes senescent. However, telomerase can keep the length of telomeres intact, even after cell division."

In practice, he added, telomere length is a laboratory measure of a cell's "age." Some cells avoid aging by using telomerase to lengthen their telomeres through the addition of DNA sequences, thereby maintaining their capacity to multiply and "stay young."

In an embryo, where tissue is still in the formative stage, telomerase is expressed by practically every cell. After this period, only cells that are constantly dividing, such as hematopoietic (blood-forming) stem cells, which can differentiate into a variety of specialized cells, continue to produce telomerase.

"Aplastic anemia is one of the diseases that can be caused by telomerase deficiency," Calado said. "Bone marrow stem cells age prematurely and fail to produce enough red blood cells, white blood cells and platelets, making the patient dependent on blood transfusions and more susceptible to infections."

In 2009, Calado and collaborators published an article in the journal Blood showing that androgens, which are converted into estrogens in humans, bind to female hormone receptors in the telomerase gene promoter region and thereby stimulate expression of the enzyme in cells.

"The study we've just published was designed to find out whether the effect we'd observed in the lab also occurred in humans, and the results indicate that it does," Calado said.

Instead of estrogen, the researchers treated the patients with androgen, he explained, because it has long been used as a drug in cases of congenital anemia and offers the advantage of stimulating an increase in the mass of hemoglobin (red blood cells), which estrogen cannot do.

Treatment with the steroid danazol, a synthetic male hormone, was tested for two years in 27 patients with aplastic anemia owing to telomerase gene mutations.

"In a healthy adult, telomere length varies from 7,000 to 9,000 base pairs on average. A normal person's telomeres lose 50 to 60 base pairs per year, but a patient with telomerase deficiency can lose between 100 and 300 base pairs per year," Calado said. "In the patients who received danazol, telomere length increased by 386 base pairs on average over two years."

In addition, hemoglobin mass rose from 9 grams per deciliter (g/dL) to 11 g/dL on average. A person without anemia normally has between 12 and 16 g/dL, but the improvement observed in these subjects was sufficient to rid them of transfusion dependency.

"On completion of the protocol, the medication was interrupted, and we observed a fall in all counts. Several patients resumed the medication with smaller doses, individually adjusted to minimize side effects," Calado said.

In a new protocol currently in progress at the University of São Paulo's Ribeirao Preto Blood Center, the same kind of approach is being tested with nandrolone, an injectable male hormone.

Although the results of the study suggest that drugs can be used to reverse one of the biological drivers of aging, it is not yet clear whether the benefits of treatment would surpass the risks in healthy people, especially if the treatment involved the use of sex hormones.

Some groups, such as patients undergoing chemotherapy or radiotherapy, may benefit from drugs that stimulate telomerase in the future.

Story Source:

Materials provided by Fundação de Amparo à Pesquisa do Estado de São Paulo. Note: Content may be edited for style and length.

Journal Reference:

Danielle M. Townsley, Bogdan Dumitriu, Delong Liu, Angélique Biancotto, Barbara Weinstein, Christina Chen, Nathan Hardy, Andrew D. Mihalek, Shilpa Lingala, Yun Ju Kim, Jianhua Yao, Elizabeth Jones, Bernadette R. Gochuico, Theo Heller, Colin O. Wu, Rodrigo T. Calado, Phillip Scheinberg, Neal S. Young. Danazol Treatment for Telomere Diseases. New England Journal of Medicine, 2016; 374 (20): 1922 DOI: 10.1056/NEJMoa1515319
__________________
ADMIN/OWNER@Peak-Muscle
liftsiron is online now   Reply With Quote
Links


Old 03-05-2018, 10:05 AM   #2
liftsiron
Administrator
 
liftsiron's Avatar
 

Join Date: Nov 2003
Location: Cimmeria
Posts: 15,890
liftsiron has much to be proud ofliftsiron has much to be proud ofliftsiron has much to be proud ofliftsiron has much to be proud ofliftsiron has much to be proud ofliftsiron has much to be proud ofliftsiron has much to be proud ofliftsiron has much to be proud ofliftsiron has much to be proud of
Bump!
__________________
ADMIN/OWNER@Peak-Muscle
liftsiron is online now   Reply With Quote
Reply


Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump


All times are GMT -5. The time now is 07:05 AM.


Powered by: vBulletin Version 3.6.8
Copyright ©2000 - 2018, Jelsoft Enterprises Ltd.