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Old 02-19-2018, 02:21 AM   #1
Dawgpound_Hank
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Deca dick explained

http://www.musculardevelopment.com/a...l#.Wop5bq6nHIV

Written by Steve Blechman 15 February 2018

New Study: 'DECA DICK' EXPLAINED AT LAST!
Anabolic Steroid Nandrolone Inhibits Nitric Oxide!


Holy shit! What the fuck?!



Now we know why nandrolone, an anabolic steroid (also known as 19-nortestosterone used in the form of esters such as nandrolone decanoate/Deca-Durabolin) causes erectile dysfunction and is often referred to as “Deca Dick.” This synthetic anabolic steroid has been available for decades. Early potential uses were for osteoporosis, anemia and muscle wasting. Anecdotal reports by bodybuilders suggest that nandrolone decreases joint pain from lifting heavy weights. Nandrolone binds to androgen receptors with greater binding affinity than testosterone, contributing to enhanced muscle growth. Nandrolone esters are among the most widely used steroids worldwide for medical use and to improve physique and performance.



A new study in the Journal Steroids, March 2018, found that nandrolone combined with strenuous resistance training reduces vascular nitric oxide bioavailability and impairs endothelium-dependent vasodilation. Nandrolone can inhibit erectile function and cause sexual impairment as well as increase blood pressure and cardiovascular disease. Nandrolone plus strenuous resistance training increased reactive oxygen species (ROS, free radicals) that damage cellular tissues. It also drastically reduced vascular nitric oxide bioavailability. Nandrolone also increased arterial wall thickening and endothelial dysfunction. Nandrolone may increase the risk of cardiovascular disease and erectile dysfunction by decreasing dihydrotestosterone (DHT!), which is the active androgen involved in nitric oxide-meditated penile erections. Transdermal DHT is aging men has been shown to increase early morning erections and ability to maintain them.



5-alpha-reductase enzyme normally converts testosterone in the prostate gland and hair follicle to DHT. DHT can cause prostate enlargement and alopecia (hair loss). Treatment of benign prostatic hypertrophy and alopecia with the drug finasteride lowers DHT but has side effects such as erectile and endothelial dysfunction. I am very concerned that finasteride taken for hair loss and benign prostatic hypertrophy may cause erectile and endothelial dysfunction and increase the risk of cardiovascular disease!



Many anabolic steroid users use nandrolone because it does not convert into DHT. DHT can enhance hair loss (alopecia). This is one of the reasons why men use nandrolone, or Deca, as a replacement for testosterone because it could alleviate the development of androgenic alopecia. Because nandrolone does not raise DHT, it has less effect on hair loss than exogenous testosterone (with its subsequent conversion to DHT). That’s why nandrolone may be beneficial in hypogonadal men concerned with alopecia. The downside is that while nandrolone might prevent alopecia hair loss, it may have detrimental effects on endothelial vascular and erectile function and increased potential risk of cardiovascular disease.



Nandrolone use lowers levels of luteinizing hormone and testosterone through negative feedback therefore, lowering DHT formation, but DHT is required for proper nitric oxide function. By inhibiting DHT, you lower nitric oxide bioavailability and endothelial function. It is theorized that nandrolone should be administered with testosterone (“stacked”) to provide DHT and prevent erectile dysfunction. However, specific in-vivo studies examining the effects of testosterone with nandrolone in humans have not been published. Very little scientific research exists regarding the use of nandrolone and, as such— further human studies are needed.



Twitter @SBlechmanARM



References:

Nandrolone combined with strenuous resistance training reduces vascular nitric oxide bioavailability and impairs endothelium-dependent vasodilation. Steroids, Volume 131, March 2018. Pages 7-13.

Long-term treatment with Nandrolone Decanoate impairs mesenteric vascular relaxation in both sedentary and exercised female rats. Steroids, Volume 120, April 2017. Pages 7-18.
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Old 02-19-2018, 02:03 PM   #2
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Good post most we all are aware of but This is the first I’ve heard of it having any affect on nitric oxide. Interesting
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Old 02-19-2018, 02:42 PM   #3
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I still feel strongly that nandrolone induced ED is more related to progestin signaling in the arcuate nucleus which releases prolactin which can be reversed by increased dopamine signaling.
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Old 02-19-2018, 02:56 PM   #4
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I still feel strongly that nandrolone induced ED is more related to progestin signaling in the arcuate nucleus which releases prolactin which can be reversed by increased dopamine signaling.
Mmmm true. You think b6 post cycle would suffice or keep up with prami or caber?
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Old 02-19-2018, 06:08 PM   #5
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Deca used to be part of my base all the time. I never once had an issue on Deca and always considered it psychological. Maybe there is something to it.
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Old 02-19-2018, 06:25 PM   #6
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.....progestin signaling in the arcuate nucleus which releases prolactin which can be reversed by increased dopamine signaling.


r (.734)^ xy * p (t^)
--------------------------
3.67779e / (.06)

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Old 02-19-2018, 06:35 PM   #7
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Deca used to be part of my base all the time. I never once had an issue on Deca and always considered it psychological. Maybe there is something to it.
Past 10 years if I ran it it was around 300mg ew usually with 500-600mg ew test. No problemo. Back in '05 I ran it 600mg ew with 750mg ew test, and bonerz weren't the normal steel-like & also took longer to get a nutt.
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Old 02-19-2018, 06:49 PM   #8
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r (.734)^ xy * p (t^)
--------------------------
3.67779e / (.06)

Lol I thought Iwas the only one. Never had an issue but I've never gone over 400mg
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Old 02-20-2018, 04:04 AM   #9
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Very nice find. I like the DHT angle as I have found that a little proviron prevents any erectile problems for me when on deca. Test,deca, var and provi works very well for me.
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Old 02-21-2018, 04:07 PM   #10
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Very nice find. I like the DHT angle as I have found that a little proviron prevents any erectile problems for me when on deca. Test,deca, var and provi works very well for me.
Damn that sounds like an awesome cycle. I gotta try that one out sometime.

Only ran proviron once - waaaayy back when I joined IT I remember Forte (remember him Lifts?) telling me to run provirion with test to increase effects via lowering SHBG (sp? ). I was walking wood with 50mg ed of prov.
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Old 02-21-2018, 05:51 PM   #11
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I still feel strongly that nandrolone induced ED is more related to progestin signaling in the arcuate nucleus which releases prolactin which can be reversed by increased dopamine signaling.
He's really sexy when he talks like that....
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Old 02-22-2018, 05:20 AM   #12
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Damn that sounds like an awesome cycle. I gotta try that one out sometime.

Only ran proviron once - waaaayy back when I joined IT I remember Forte (remember him Lifts?) telling me to run provirion with test to increase effects via lowering SHBG (sp? ). I was walking wood with 50mg ed of prov.

I remember Forte well, I haven't heard that name in quite awhile.
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Old 02-24-2018, 09:42 PM   #13
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Old 02-26-2018, 04:58 AM   #14
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Funny how guys from back in the day stop posting sometimes
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