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Old 04-05-2021, 04:42 PM   #1
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Muscular exercise can cause highly pathological liver function tests

Comparative Study
Br J Clin Pharmacol

. 2008 Feb;65(2):253-9.
doi: 10.1111/j.1365-2125.2007.03001.x. Epub 2007 Aug 31.
Muscular exercise can cause highly pathological liver function tests in healthy men
Jonas Pettersson 1 , Ulf Hindorf, Paula Persson, Thomas Bengtsson, Ulf Malmqvist, Viktoria Werkström, Mats Ekelund
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PMID: 17764474 PMCID: PMC2291230 DOI: 10.1111/j.1365-2125.2007.03001.x

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Abstract

What is already known about this subject: The occurrence of idiosyncratic drug hepatotoxicity is a major problem in all phases of clinical drug development and the leading cause of postmarketing warnings and withdrawals. Physical exercise can result in transient elevations of liver function tests. There is no consensus in the literature on which forms of exercise may cause changes in liver function tests and to what extent.

What this study adds: Weightlifting results in profound increases in liver function tests in healthy men used to moderate physical activity, not including weightlifting. Liver function tests are significantly increased for at least 7 days after weightlifting. It is important to impose relevant restrictions on heavy muscular exercise prior to and during clinical studies.

Aim: To investigate the effect of intensive muscular exercise (weightlifting) on clinical chemistry parameters reflecting liver function in healthy men.

Methods: Fifteen healthy men, used to moderate physical activity not including weightlifting, performed an 1 h long weightlifting programme. Blood was sampled for clinical chemistry parameters [aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LD), gamma-glutamyl transferase (gamma GT), alkaline phosphatase (ALP), bilirubin, creatine kinase (CK) and myoglobin] at repeated intervals during 7 days postexercise and at a follow-up examination 10-12 days postexercise.

Results: Five out of eight studied clinical chemistry parameters (AST, ALT, LD, CK and myoglobin) increased significantly after exercise (P < 0.01) and remained increased for at least 7 days postexercise. Bilirubin, gamma GT and ALP remained within the normal range.

Conclusion: The liver function parameters, AST and ALT, were significantly increased for at least 7 days after the exercise. In addition, LD and, in particular, CK and myoglobin showed highly elevated levels. These findings highlight the importance of imposing restrictions on weightlifting prior to and during clinical studies. Intensive muscular exercise, e.g. weightlifting, should also be considered as a cause of asymptomatic elevations of liver function tests in daily clinical practice.
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Old 04-05-2021, 04:55 PM   #2
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I did a 2.5 hour workout one morning and then went and gave blood for a liver panel immediately afterwards and both my ALT and AST were greatly increased.
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Old 04-09-2021, 12:43 PM   #3
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Trying to figure out what this means. What I've gathered so far is that intense exercise which is historically known to be healthy in all ways for the body seems to elevate liver enzymes? Does this mean the liver is stressed? If so is this stress good or bad? Does it mean the liver is increasing it's filtration and chemical output as a result of muscle breakdown and metabolic changes required to continue the exercise hence the body getting stronger?

This is very interesting
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Old 04-09-2021, 12:58 PM   #4
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Originally Posted by kriegernindo View Post
Trying to figure out what this means. What I've gathered so far is that intense exercise which is historically known to be healthy in all ways for the body seems to elevate liver enzymes? Does this mean the liver is stressed? If so is this stress good or bad? Does it mean the liver is increasing it's filtration and chemical output as a result of muscle breakdown and metabolic changes required to continue the exercise hence the body getting stronger?

This is very interesting
It means that slightly elevated liver enzymes is normal following intense exercise.
It does not indicate liver damage or stress to the liver.
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Old 04-09-2021, 01:21 PM   #5
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Ahh okay. Understandable. The liver is the most amazing organ. Producer of over 1000 chemicals per day. (if it's healthy)

The liver even produces blood thinning substances. Amazing.

Ive started on this product called stone breaker. Breaks down stones in the liver and kidneys. Feel better on it than I have in years

Chanca piedra
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Old 12-05-2021, 06:21 AM   #6
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Good to know!
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Old 12-09-2021, 06:27 PM   #7
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I am surprised and relieved to find out it causes elevation for 7 days! My liver enzymes have been a little over the normal range for past few years. But I still train the same and don’t even use orals anymore. They used to only be elevated when I was on orals. I guess I’m getting old. Probably nothing to worry about. I try not to workout for a couple days before a blood test because I know it can elevate creatinine too. Not sure I can take a full week off before though. But would be interesting to see if it makes a difference.
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Old 04-18-2022, 02:04 PM   #8
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Bump.
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Old 07-12-2022, 11:08 AM   #9
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I have slightly elevated alt and ast. I went to a liver specialist for a complete workup. Nothing at all wrong.
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