Peak-Muscle.com  

Welcome to the Peak-Muscle.com forums.

You are currently viewing our boards as a guest which gives you limited access to view most discussions and access our other features. Come join us in on one of the best online fitness communities. We have 16,000 members that are likeminded towards a fitness, bodybuilding lifestyle. Registration is free and only takes but a few minutes. By joining our free community you will have access to communicate privately with other members (PM), respond to polls, upload content and access many other special features. You will be able to create threads to discuss and or create a fitness regimen. Or just bounce ideas off of some very knowledgeable members. So don't miss out. Registration is fast, simple and absolutely free so please, join our community today!

Register FAQ Members List Calendar Arcade Mark Forums Read
Go Back   Peak-Muscle.com > Anabolic Steroid Discussion > Prohormones/Research Chems
User Name
Password

 
 
Thread Tools Display Modes
Prev Previous Post   Next Post Next
Old 02-24-2021, 01:26 PM   #1
liftsiron
Administrator
 
liftsiron's Avatar
 

Join Date: Nov 2003
Location: Cimmeria
Posts: 18,163
liftsiron has much to be proud ofliftsiron has much to be proud ofliftsiron has much to be proud ofliftsiron has much to be proud ofliftsiron has much to be proud ofliftsiron has much to be proud ofliftsiron has much to be proud ofliftsiron has much to be proud ofliftsiron has much to be proud ofliftsiron has much to be proud of
Tadalafil improves lean mass and endothelial function in nonobese men

Randomized Controlled Trial
Endocrine

. 2017 Jun;56(3):639-648.
doi: 10.1007/s12020-016-1208-y. Epub 2017 Jan 30.
Tadalafil improves lean mass and endothelial function in nonobese men with mild ED/LUTS: in vivo and in vitro characterization
Antonio Aversa 1 , Simona Fittipaldi 2 , Davide Francomano 3 , Viviana M Bimonte 4 , Emanuela A Greco 3 5 , Clara Crescioli 4 , Luigi Di Luigi 4 , Andrea Lenzi 3 , Silvia Migliaccio 4
Affiliations

PMID: 28133708 DOI: 10.1007/s12020-016-1208-y

Abstract

Purpose: Phosphodiesterase type-5 inhibitor administration in diabetic men with erectile dysfunction (ED) is associated with reduced waist circumference. We evaluated potential effects of daily tadalafil administration on body composition and investigated its possible mechanism(s) of action in C2C12 skeletal muscle cells in vitro.

Methods: Forty-three men on stable caloric intake (mean age 48.5 7; BMI 25.5 0.9 kg/m2) complaining mild ED and/or low urinary tract symptoms (LUTS) were randomly assigned to receive tadalafil (TAD) 5 mg/daily (once-a-day=OAD-TAD; n = 23) or 20 mg on-demand (on-demand=OD-TAD; n = 20) for 2 months. Primary outcomes were variations of body composition measured by Dual-energy X-ray absorptiometry; secondary outcomes were ED/LUTS questionnaire scores along with hormone (testosterone, estradiol, insulin) and endothelial function (Endopat2000) variations.

Results: OAD-TAD increased abdominal lean mass (p < 0.01) that returned to baseline after 2 months withdrawal. LUTS scores improved (p<0.01) in OD-TAD while ED scores improved (p < 0.01) in both groups. We found significant improvements in endothelial function (p < 0.05) that directly correlated with serum insulin (p < 0.01; r = 0.3641) and inversely correlated with estradiol levels (p < 0.01; r = 0.3655) even when corrected for potential confounders. Exposure of C2C12 cells upon increasing tadalafil concentrations (10-7 to 10-6 M) increased total androgen receptor mRNA and protein expression as well as myogenin protein expression after 24 and 72 h (2.8 0.4-fold and 1.4 0.02-fold vs. control, respectively, p < 0.05).

Conclusions: Daily tadalafil improved lean mass content in non-obese men probably via enhanced insulin secretion, estradiol reduction, and improvement of endothelial function in vivo. The in vitro increased myogenin and androgen receptor protein expression in skeletal muscle cells suggests a translational action of phosphodiesterase type-5 on this receptor.

Keywords: Androgen receptor; Erectile Dysfunction; Estradiol; Fat mass; Lower Urinary Tract Symptoms; Phosphodiesterase type-5; Skeletal muscle; Testosterone.
__________________
ADMIN/OWNER@Peak-Muscle
liftsiron is online now   Reply With Quote
 

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Forum Jump


All times are GMT -5. The time now is 08:16 PM.


Powered by: vBulletin Version 3.8.11
Copyright ©2000 - 2023, Jelsoft Enterprises Ltd.